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Why friendships could be good for your gut

<p dir="ltr">As well as being good for our mental health, it seems that having plenty of friends can be good for the health of our gut, a new study says.</p> <p dir="ltr">Scientists looked at a group of Rhesus Macaques living on Cayo Santiago, an island off the coast of Puerto Rico, and found that the more sociable primate had more beneficial bacteria and less harmful bacteria than less social monkeys.</p> <p dir="ltr">To measure just how social the monkeys were, the researchers measured the time each monkey spent grooming or being groomed by others, as well as the number of grooming partners they had.</p> <p dir="ltr">“Macaques are highly social animals and grooming is their main way of making and maintaining relationships, so grooming provides a good indicator of social interactions,” Dr Kali Watson, a cognitive scientist at the University of Colorado, said.</p> <p dir="ltr">They also collected faecal samples from the monkeys and performed DNA sequencing to measure the composition and diversity of gut microbes that were present.</p> <p dir="ltr">“Engagement in social interactions was positively related to the abundance of certain gut microbes with beneficial immunological functions, and negatively related to the abundance of potentially pathogenic members of the microbiota,” Dr Philip Burnet, who researches the influence of the gut microbiome on brain health at the University of Oxford, said.</p> <p dir="ltr">They found that the most sociable monkeys had higher levels of protective bacteria, including <em>Faecalibacterium</em>, which has anti-inflammatory properties, and <em>Prevotella</em>, which has been associated with better immunity against pathogens and anti-inflammatory effects.</p> <p><span id="docs-internal-guid-0dd63408-7fff-3ddf-b8be-419de6dceec8"></span></p> <p dir="ltr">Meanwhile, bacteria such as <em>Streptococcus</em>, which cause diseases such as strep throat and pneumonia, were found in greater abundance in the less social monkeys.</p> <p dir="ltr"><img src="https://oversixtydev.blob.core.windows.net/media/2022/12/monkey-guts1.jpg" alt="" width="1280" height="720" /></p> <p dir="ltr"><em>Image: Frontiers Press</em></p> <p dir="ltr">As for why this happens, the researchers proposed that it may be to do with the transmission of bacteria through physical contact, such as grooming.</p> <p dir="ltr">“The relationship between social behaviour and microbial abundances may be the direct result of social transmission of microbes, for example through grooming,” Dr Katerina Johnson, a researcher at the University of Oxford, said. </p> <p dir="ltr">“It could also be an indirect effect, as monkeys with fewer friends may be more stressed, which then affects the abundance of these microbes. </p> <p dir="ltr">“As well as behaviour influencing the microbiome, we also know it is a reciprocal relationship, whereby the microbiome can in turn affect the brain and behaviour.”</p> <p dir="ltr">The millions of bacteria, fungi and other microorganisms that live in our gut - and make up our <a href="https://www.oversixty.com.au/health/mind/your-gut-s-second-brain-may-have-evolved-before-your-head-s-brain">gut microbiome</a> - have become an area of interest for researchers, particularly when it comes to digestive health and the influence it has on our nervous system, in a relationship called the <a href="https://www.oversixty.com.au/health/mind/how-gut-bacteria-could-affect-your-mental-health">‘gut-brain axis’</a>.</p> <p dir="ltr">Previous studies have shown that the levels of different species of these organisms in our guts have been linked to depression, schizophrenia and even autoimmune conditions such as Crohn’s disease and colitis. The gut even creates neurotransmitters, hormones and other molecules the brain needs.</p> <p dir="ltr">With this study finding that being social can influence our gut, which in turn can influence our health more generally, it shows just how crucial social interactions are for our health.</p> <p dir="ltr">Dr Robin Dunbar, a psychology professor at the University of Oxford, said: “As our society is increasingly substituting online interactions for real-life ones, these important research findings underline the fact that as primates, we evolved not only in a social world but a microbial one as well.”</p> <p dir="ltr">The researchers published their findings in the journal <em><a href="https://doi.org/10.3389/fmicb.2022.1032495" target="_blank" rel="noopener">Frontiers in Microbiology</a></em>.</p> <p dir="ltr"><span id="docs-internal-guid-2a928ab1-7fff-d510-19e0-817d118030bc"></span></p> <p dir="ltr"><em>Image: Frontiers Press</em></p>

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Celine Dion reveals shock diagnosis

<p dir="ltr">Céline Dion has revealed she has been diagnosed with a rare neurological condition and has cancelled her upcoming Courage world tour.</p> <p dir="ltr">The Canadian songstress shared the news during an emotional video on Instagram, informing fans that she has Stiff Person Syndrome (SPS), a rare disorder that affects the nervous symptom and causes extreme muscle stiffness and painful spasms.</p> <p dir="ltr">“Recently I’ve been diagnosed with a very rare neurological disorder called the stiff person syndrome, which affects 1 in a million people,” Dion said in the clip.</p> <p dir="ltr">"While we're still learning about this rare condition, we now know this is what's been causing all of the spasms that I've been having.</p> <p><span id="docs-internal-guid-11b08fca-7fff-f409-f618-2c1eb0a389b3"></span></p> <p dir="ltr">"Unfortunately these spasms affect every aspect of my daily life, sometimes causing difficulties when I walk and not allowing me to use my vocal chords to sing the way I'm used to."</p> <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/reel/Cl5xJY1AjAO/?utm_source=ig_embed&utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/reel/Cl5xJY1AjAO/?utm_source=ig_embed&utm_campaign=loading" target="_blank" rel="noopener">A post shared by Céline Dion (@celinedion)</a></p> </div> </blockquote> <p dir="ltr">According to the <a href="https://stiffperson.org/sps-101/treatments-for-sps/" target="_blank" rel="noopener">Stiff Person Syndrome Research Foundation</a>, SPS affects between 1-2 in one million people and is more common in women than men.</p> <p dir="ltr">While there is no cure for SPS currently, the symptoms can be treated with medication and therapies.</p> <p dir="ltr">The <em>My Heart Will Go On</em> singer said she would be unable to restart her world tour in Europe next February, when she was due to tour in Germany, Switzerland, Poland, Hungary, Austria, Croatia, and the UK.</p> <p dir="ltr">She said eight tour dates would be cancelled and rescheduled to 2024.</p> <p dir="ltr">The news comes after the five-time Grammy winner cancelled the North American leg of her tour earlier this year.</p> <p dir="ltr">In the video, Dion thanked fans for their well-wishes and her children for their support, telling fans she was working with medical therapists to build her strength and ability to perform again.</p> <p dir="ltr">"I always give 100 percent when I do my shows, my condition is not allowing me to give you that right now," the 54-year-old said. </p> <p dir="ltr">"For me to reach you again I have no choice but to concentrate on my health at this moment and I have hope that I'm on the road to recovery.</p> <p dir="ltr">“This is my focus and I’m doing everything I can to recuperate."</p> <p dir="ltr"><span id="docs-internal-guid-58aa65bb-7fff-1527-64d0-6d77b30219e8"></span></p> <p dir="ltr"><em>Image: Instagram</em></p>

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Chris Hemsworth’s Alzheimer’s gene doesn’t guarantee he’ll develop dementia

<p>Chris Hemsworth, famous for his role as the god Thor in Marvel Cinematic Universe movies, has announced he will be <a href="https://www.theguardian.com/film/2022/nov/21/chris-hemsworth-to-take-time-off-from-acting-after-discovering-alzheimers-risk" target="_blank" rel="noopener">taking a break</a> from acting after being told he has two copies of the <a href="https://www.nia.nih.gov/news/study-reveals-how-apoe4-gene-may-increase-risk-dementia" target="_blank" rel="noopener">APOE4 gene</a>, increasing his risk of Alzheimer’s.</p> <p>Having one copy of the <a href="https://www.science.org/doi/abs/10.1126/science.8346443" target="_blank" rel="noopener">APOE4 gene</a> increases your risk for Alzheimer’s 2-3 times. Two copies increases your risk 10-15 times.</p> <p>But the key here is “risk”. Having one or more copies of the gene doesn’t guarantee Chris or anyone else in a similar situation will go on to develop Alzheimer’s, the most common form of dementia.</p> <p><strong>Sharing the news</strong></p> <p>Hemsworth’s willingness to share his concerns about developing Alzheimer’s with millions should be applauded. It’s a reminder to all of us to keep an eye on our health and reduce our risk of future illness.</p> <p>Alzheimer’s, and dementia more broadly, is <a href="https://www.dementiastatistics.org/statistics/global-prevalence/" target="_blank" rel="noopener">set to challenge</a> health-care systems worldwide.</p> <p>In Australia alone there are <a href="https://www.dementia.org.au/statistics" target="_blank" rel="noopener">up to</a> 500,000 people with dementia, supported by almost 1.6 million carers. By 2036, about <a href="https://www.dementia.org.au/sites/default/files/NATIONAL/documents/The-economic-cost-of-dementia-in-Australia-2016-to-2056.pdf" target="_blank" rel="noopener">450 people</a> are predicted to be diagnosed daily. So understanding how APOE4 alters the risk for the major cause of dementia may be pivotal in preventing cases.</p> <p>But not all people with the APOE4 gene go on to develop Alzheimer’s. This means that there may be a combination of environmental factors interplaying with the gene that lead some people to develop Alzheimer’s, while others do not.</p> <p><strong>What’s APOE4 got to do with Alzheimer’s?</strong></p> <p>Most Australians have APOE3 or APOE2 genes. In Caucasians it’s only <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531868/" target="_blank" rel="noopener">about 15%</a>, like Hemsworth, who have inherited an APOE4 gene.</p> <p>The APOE gene types are best known for their role in modulating the metabolism of lipids (fats), such as cholesterol and triglycerides.</p> <p>They code for synthesis of different versions of the protein APOE, with subtle differences in structure. The APOE proteins become an integral part of lipoproteins in the blood. These are the fat-carrying particles your GP measures to consider your risk of heart disease.</p> <p>APOE proteins have a similar function in the brain, to modulate lipid levels. But in the context of Alzheimer’s, researchers study it for its effect on the integrity of brain cells.</p> <p>Accumulating evidence <a href="https://www.sciencedirect.com/science/article/pii/S0197458022000550" target="_blank" rel="noopener">suggests</a> APOE4, is associated with brain inflammation and cellular damage.</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">APOE4 is the strongest genetic risk factor for Alzheimer’s disease. A study in <a href="https://twitter.com/Nature?ref_src=twsrc%5Etfw">@Nature</a> establishes a functional link between APOE4, cholesterol, myelination and memory, offering therapeutic opportunities for Alzheimer’s disease. <a href="https://t.co/bNsmDVPfFW">https://t.co/bNsmDVPfFW</a> <a href="https://t.co/58odE1JASl">pic.twitter.com/58odE1JASl</a></p> <p>— Nature Portfolio (@NaturePortfolio) <a href="https://twitter.com/NaturePortfolio/status/1594762841487249410?ref_src=twsrc%5Etfw">November 21, 2022</a></p></blockquote> <p><strong>Can we prevent Alzheimer’s?</strong></p> <p><strong>1. Look after your capillaries</strong></p> <p>Damaged and leaky blood vessels (capillaries) in the brain lead to inflammation, the death of brain cells and cognitive impairment. In fact, in Alzheimer’s, damaged capillaries are the earliest sign of the type of brain damage that causes disease.</p> <p>The protein encoded by the APOE4 gene may be less able to support healthy capillaries in the brain. <a href="https://www.sciencedirect.com/science/article/abs/pii/S0163782709000563" target="_blank" rel="noopener">We suggested</a> APOE4 increases the abundance of specific complexes of lipoproteins and proteins in blood that silently damage brain capillaries, causing them to leak.</p> <p>We also see more brain capillary leakage in mice fed Western-style diets richer in saturated fats.</p> <p>The relationship between how the APOE proteins mediate lipid metabolism and capillary health in humans is poorly understood.</p> <p>But we have 60 years of research knowledge to say with confidence that eating foods good for the heart should also be good for the brain. This is particularly relevant for people with the APOE4 gene.</p> <p>So if you have the APOE4 gene and want to minimise your risk of Alzheimer’s, a healthy diet is a good place to start.</p> <figure class="align-center zoomable"><em><a href="https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=1000&amp;fit=clip"><img src="https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=600&amp;h=316&amp;fit=crop&amp;dpr=1 600w, https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=600&amp;h=316&amp;fit=crop&amp;dpr=2 1200w, https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=600&amp;h=316&amp;fit=crop&amp;dpr=3 1800w, https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;h=397&amp;fit=crop&amp;dpr=1 754w, https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=754&amp;h=397&amp;fit=crop&amp;dpr=2 1508w, https://images.theconversation.com/files/497142/original/file-20221124-24-rlqyk5.jpg?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=754&amp;h=397&amp;fit=crop&amp;dpr=3 2262w" alt="Capillaries" /></a></em><figcaption><em><span class="caption">Looking after your capillaries with a healthy diet is a good place to start.</span> <span class="attribution"><a class="source" href="https://www.shutterstock.com/image-illustration/system-many-small-capillaries-branch-out-1745173364" target="_blank" rel="noopener">Shutterstock</a></span></em></figcaption></figure> <p><strong>2. Give your brain a break</strong></p> <p>Reducing unnecessary stimuli to “give your brain a rest” may have big impact over decades of your life. The latter may be a more important consideration if you have the APOE4 gene.</p> <p>That’s because the APOE gene is also linked to how the brain uses energy, which may lead to more <a href="https://www.frontiersin.org/articles/10.3389/fnmol.2018.00216/full" target="_blank" rel="noopener">oxidative stress and damage</a>.</p> <p>While we’ve yet to collect robust data in humans, take a digital detox now and again, plan some down time, and avoid unnecessary stress if you can.</p> <p><strong>Should we test for the APOE4 gene?</strong></p> <p>Some people might be tempted to get tested for the APOE4 gene, especially if there’s a family history of Alzheimer’s.</p> <p>But unless genetic testing is going to change your treatment (for instance, by taking certain medications to slow progression of brain damage), or your behaviour to minimise your risk Alzheimer’s, then testing is not justified.</p> <p>We can’t change the genes our parents gifted us, but we can change our environment.</p> <p>Poor diet, every drop of alcohol you drink, obesity and diabetes, high blood pressure and sedentary behaviour <a href="https://www.dementia.org.au/risk-reduction" target="_blank" rel="noopener">all contribute, over time</a>, to poorer vascular health and increase your risk of dementia.</p> <p>We’re still learning about how these risk factors for Alzheimer’s interact with the APOE4 gene. But there is no reason we shouldn’t all take greater responsibility for minimising our risk of dementia now, whether we have the APOE4 gene or not.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/195094/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><em>Writen by John Mamo. Republished with permission from <a href="https://theconversation.com/chris-hemsworths-alzheimers-gene-doesnt-guarantee-hell-develop-dementia-heres-what-we-can-all-do-to-reduce-our-risk-195094" target="_blank" rel="noopener">The Conversation</a>.</em></p> <p><em>Image: Instagram</em></p>

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Are you smarter than a 5th grader? Probably not

<p dir="ltr">We’ve long suspected that children are “smarter” than us and can learn much faster than adults - but now science has confirmed it as all but true and explained why.</p> <p dir="ltr">A new study has found that children learning something new experience a rapid boost in GABA, a brain messenger that helps to stabilise newly-learned material, while adults don’t.</p> <p dir="ltr">“Our results show that children of elementary school age can learn more items within a given period of time than adults, making learning more efficient in children,” Takeo Watanabe, a professor in cognitive and linguistic sciences, said.</p> <p dir="ltr">With previous research only looking at changes in levels of GABA at a single time-point that wasn’t at a specific time in relation to learning, the scientists set out to measure the levels of GABA in children and adults before, during and after undergoing visual training.</p> <p dir="ltr">They found that learning something visually triggered an increase in GABA in the visual cortex - the area of the brain that processes information - in children that lasted for several minutes after the training ended.</p> <p dir="ltr">But, this increase wasn’t observed in adults, with no changes in GABA levels seen at all.</p> <p dir="ltr">This suggests that children’s brains respond to learning in a way that enables them to learn more quickly and stabilise information faster.</p> <p dir="ltr">“It is often assumed that children learn more efficiently than adults, although the scientific support for this assumption has, at best, been weak, and, if it is true, the neuronal mechanisms responsible for more efficient learning in children are unclear,” Professor Watanabe said.</p> <p dir="ltr">With this finding also suggesting that the concentration of GABA would rapidly increase in children’s brains as a result of training, which would allow for the new information learnt to rapidly stabilise, the team also tested whether this would be true.</p> <p dir="ltr">“In subsequent behavioural experiments, we found that children indeed stabilised new learning much more rapidly than adults, which agrees with the common belief that children outperform adults in their learning abilities,” Dr Sebastian Frank, a cognitive neuroscientist and the study’s first author, explained.</p> <p dir="ltr">“Our results therefore point to GABA as a key player in making learning efficient in children.”</p> <p dir="ltr">He said that their results imply that the increased levels of GABA help children outperform adults despite having poorer cognitive control and attention.</p> <p dir="ltr">“Although children’s brains are not yet fully matured and many of their behavioural and cognitive functions are not as efficient as in adults, children are not, in general, outperformed in their abilities by adults,” Professor Watanabe added.</p> <p dir="ltr">“On the contrary, children are, at least in some domains such as visual learning, superior in their abilities to adults.”</p> <p dir="ltr">The researchers said their findings should be explored further in future studies, particularly looking at differences in how the different brain regions mature, as well as how GABA levels affect other types of learning, such as reading and writing.</p> <p dir="ltr">They published their findings in the journal <em><a href="https://doi.org/10.1016/j.cub.2022.10.021" target="_blank" rel="noopener">Current Biology</a></em>.</p> <p><span id="docs-internal-guid-b6f8700a-7fff-0a60-6db5-638f99eec3f2"></span></p> <p dir="ltr"><em>Image: Getty Images</em></p>

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Man who lived in airport for 18 years dies

<p dir="ltr">The man who inspired Steven Spielberg’s <em>The Terminal</em>, as well as a French film and an opera, has died in the airport where he lived for 18 years.</p> <p dir="ltr">Mehran Karimi Nasseri suffered a heart attack in Terminal 2F of the Charles de Gaulle airport on Saturday and died after police and a medical team were unable to save him, according to an official with the Paris airport.</p> <p dir="ltr">Mr Nasseri, believed to have been born in 1945 in Soleiman, the then-British controlled area of Iran, lived in Terminal 1 between 1988 and 2006, at first while he was in a legal limbo because he was without residency papers and later by choice.</p> <p dir="ltr">The airport official said the 76-year-old had been living in the airport again in recent weeks.</p> <p dir="ltr">His first stint at the airport, when he spent years sleeping on a red plastic bench, making friends with airport workers, showering in staff facilities and spending time writing in his diary, studying economics and watching passing travellers inspired <em>The Terminal</em> starring Tom Hanks, as well as French film <em>Lost in Transit</em> and the opera <em>Flight</em>.</p> <p><span id="docs-internal-guid-60e6406c-7fff-168d-d594-bf2658fa4d87">Mr Nasseri published his autobiography, <em>The Terminal Man</em>, the same year <em>The Terminal </em>was made.</span></p> <p><img src="https://oversixtydev.blob.core.windows.net/media/2022/11/mehran-nasseri1.jpg" alt="" width="1280" height="720" /></p> <p dir="ltr"><em>Mehran Karimi Nessari lived in the Charles de Gaulle airport for 18 years, with his belongings surrounding a red plastic bench he slept on. Image: Getty Images</em></p> <p dir="ltr">After leaving Iran to study in England in 1974, he was reportedly imprisoned on his return for protesting against the shah while abroad and was exiled soon after.</p> <p dir="ltr">He applied for political asylum in several European countries and was given refugee credentials by the United Nations High Commissioner for Refugees in Belgium in 1981, but was later denied entry into England after the briefcase containing his documents was stolen at a Paris train station.</p> <p dir="ltr">Although he was arrested by French police after being sent back to Charles de Gaulle from England, he couldn’t be deported because he had no official documents and stayed.</p> <p dir="ltr">After lengthy legal campaigning, more bureaucratic bungling and increasingly strict European immigration laws kept him in a legal no-man’s land for years, Mr Nasseri was offered French and Belgian residency, but he refused to sign the papers as they listed him as Iranian and didn’t show his preferred name, Sir Alfred Mehran.</p> <p dir="ltr">He stayed at the airport for several more years before being admitted to hospital in 2006 and he later lived in a French shelter.</p> <p dir="ltr">Those at the airport who befriended him said Mr Nasseri’s years of living there had taken a toll on his mental health, while the airport doctor described him as “fossilised here” in 1990.</p> <p dir="ltr">One friend, a ticket agent, compared him to a prisoner incapable of “living on the outside”.</p> <p dir="ltr">“Eventually, I will leave the airport,” Mr Nasseri told the Associated Press in 1999, looking frail with thin hair, hollow cheeks and sunken eyes.</p> <p dir="ltr">“But I am still waiting for a passport or transit visa.”</p> <p><span id="docs-internal-guid-4bd7e308-7fff-3d7d-6c45-f058a4043631"></span></p> <p dir="ltr"><em>Image: Getty Images</em></p>

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“You are not alone”: Prince Harry pens emotional letter to bereaved children

<p dir="ltr">Prince Harry has penned a letter to children whose parents have died as a result of being in the military, telling him they share a bond in losing a parent and experiencing grief.</p> <p dir="ltr">The former royal wrote of how he learnt to cope with grief and encouraged the children to “lean into your friends” in his letter, which was shared by the charity Scotty’s Little Soldiers on Remembrance Sunday.</p> <p dir="ltr">“As many of us observe and reflect on Remembrance Sunday, I wanted to write to you and let you know you are all in my thoughts and heart today,” he began.</p> <p><span id="docs-internal-guid-319fa701-7fff-1059-e37f-7ace750a752b"></span></p> <p dir="ltr">“We share a bond even without ever meeting one another, because we share in having lost a parent. I know first-hand the pain and grief that comes with loss and want you to know that you are not alone.</p> <p dir="ltr"><img src="https://oversixtydev.blob.core.windows.net/media/2022/11/prince-harry-nov-letter.jpg" alt="" width="1280" height="720" /></p> <p dir="ltr"><em>Prince Harry penned a letter to children supported by the charity Scotty’s Little Soldiers for Remembrance Sunday. Image: Scotty’s Little Soldiers</em></p> <p dir="ltr">"While difficult feelings will come up today as we pay tribute to heroes like your mum or dad, I hope you can find comfort and strength in knowing that their love for you lives and shines on. Whenever you need a reminder of this, I encourage you to lean into your friends at Scotty’s Little Soldiers.</p> <p dir="ltr">"One of the ways I've learned to cope has been through community and talking about my grief, and I couldn't be more grateful and relieved that you have amazing people walking beside you throughout your journey.</p> <p dir="ltr">"We all know some days are harder than others, but together those days are made easier."</p> <p dir="ltr">Scotty’s Little Soldiers, a charity that supports children who have lost a parent in the military, was founded in 2010 by Nikki Scott, whose husband Corporal Lee Scott was killed in Afghanistan in 2009 and left behind two young children.</p> <p dir="ltr"><span id="docs-internal-guid-7881f497-7fff-4422-2c10-4168c81f7623"></span></p> <p dir="ltr">On Sunday, 55 children and their parents took part in the Remembrance Sunday parade wearing black and yellow scarves.</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">A proud moment for Scotty’s 💛 <a href="https://twitter.com/hashtag/RemembranceSunday?src=hash&ref_src=twsrc%5Etfw">#RemembranceSunday</a> <a href="https://t.co/CsD7wL9BQP">pic.twitter.com/CsD7wL9BQP</a></p> <p>— Scotty's L Soldiers (@CorporalScotty) <a href="https://twitter.com/CorporalScotty/status/1591767075567333378?ref_src=twsrc%5Etfw">November 13, 2022</a></p></blockquote> <p dir="ltr">In his letter, Prince Harry acknowledged that taking part in the parade would be “hard but equally important to do” to raise awareness for others.</p> <p dir="ltr">“Today you will bring new awareness to young people, just like you, who will benefit from this community of support,” he wrote.</p> <p dir="ltr">“I salute you for serving others in need, in the most honourable memory of your parent.”</p> <p dir="ltr">The Duke of Sussex has long supported the charity, which was one of the organisations chosen by Harry and Meghan Markle to benefit from donations they received as gifts for their 2018 wedding.</p> <p dir="ltr">In 2017, he met with children who’d lost a military parent at a special party on the grounds of Buckingham Palace.</p> <p dir="ltr">This year, he and Meghan attended a service on Remembrance Day to pay their respects to those who died in war across the US and the Commonwealth.</p> <p dir="ltr"><span id="docs-internal-guid-78e8d8b1-7fff-62de-8d2f-a91f99007698"></span></p> <p dir="ltr"><em>Image: Getty Images</em></p>

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COVID-19 has similar effect on brain as Parkinson’s disease

<p dir="ltr">A new study from the University of Queensland has found that being infected with COVID-19 can trigger a similar reaction in the brain to Parkinson’s disease - and they have identified a possible treatment to stop Covid’s impact on the brain in its tracks.</p> <p dir="ltr">A growing number of reports have found that Covid affects more than just our lungs, with several studies finding up to 85 percent of people with Covid, including severe, mild and asymptomatic infections, have neurological complications from being infected with the virus.</p> <p dir="ltr">This can show up in a variety of symptoms, such as headaches, dizziness, confusion, seizures, and change in mood, including depression and anxiety.</p> <p dir="ltr">The team of scientists has discovered that the virus can cause inflammation in the brain, which could make people more vulnerable to developing Parkinson's and other similar conditions.</p> <p dir="ltr">“We studied the effect of the virus on the brain’s immune cells, ‘microglia’ which are the key cells involved in the progression of brain diseases like Parkinson’s and Alzheimer’s,” Professor Woodruff said.</p> <p dir="ltr">“Our team grew human microglia in the laboratory and infected the cells with SARS-CoV-2, the virus that causes COVID-19.</p> <p dir="ltr">“We found the cells effectively became ‘angry’, activating the same pathway that Parkinson’s and Alzheimer’s proteins can activate in disease, the inflammasomes.”</p> <p dir="ltr">Inflammasomes are a kind of complex of proteins that activate inflammatory responses in the body.</p> <p dir="ltr">Dr Albornoz Balmaceda, another of the 33 authors of the study published in <em><a href="https://doi.org/10.1038/s41380-022-01831-0" target="_blank" rel="noopener">Molecular Psychiatry</a></em>, said that triggering this pathway can spark a “fire” in the brain that silently kills neurons over time in a similar way to Parkinson's and Alzheimer’s.</p> <p dir="ltr">“It’s kind of a silent killer, because you don’t see any outward symptoms for many years,” he said.</p> <p dir="ltr">“It may explain why some people who’ve had COVID-19 are more vulnerable to developing neurological symptoms similar to Parkinson’s disease.”</p> <p dir="ltr">They also found that the triggering of the inflammasome pathway was exacerbated in people who were already predisposed to developing Parkinson’s.</p> <p dir="ltr">“So if someone is already predisposed to Parkinson’s, having COVID-19 could be like pouring more fuel on that ‘fire’ in the brain,” Professor Woodruff said.</p> <p dir="ltr">“The same would apply for a predisposition for Alzheimer’s and other dementias that have been linked to inflammasomes.”</p> <p dir="ltr">While the findings are concerning, the team has also found a potential treatment that could stop the inflammation and put out the “fire” in the brain.</p> <p dir="ltr">Using inhibitory drugs developed at the University of Queensland currently being trialled with Parkinson’s patients, they found that inflammasome activation was reduced in comparison to no treatment at all.</p> <p dir="ltr">“We found it successfully blocked the inflammatory pathway activated by COVID-19, essentially putting out the fire,” Dr Balmaceda said.</p> <p dir="ltr">“The drug reduced inflammation in both COVID-19-infected mice and the microglia cells from humans, suggesting a possible treatment approach to prevent neurodegeneration in the future.”</p> <p dir="ltr">As a result, Professor Woodruff said that it means that potential treatments for Covid’s impact on the brain already exist.</p> <p dir="ltr">“Further research is needed, but this is potentially a new approach to treating a virus that could otherwise have untold long-term health ramifications,” he said.</p> <p dir="ltr"><em>Image: Getty Images</em></p>

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Robbie Coltrane’s cause of death revealed

<p dir="ltr"><em>Harry Potter</em> star Robbie Coltrane’s cause of death has been revealed, after it emerged that the British actor suffered from multiple painful health conditions prior to his death aged 72.</p> <p dir="ltr">Coltrane died from several conditions including multiple organ failure, according to his death certificate, with<em> The Sun</em> reporting that he had been unwell for some time and had been battling diabetes and obesity.</p> <p dir="ltr">According to <em>The Mirror</em>, Coltrane passed away on October 14 of sepsis - an extreme reaction to an infection - a lower respiratory tract infection and heart block - when electrical impulses that control your heart beating are disrupted.</p> <p dir="ltr">The actor, who was born Anthony Robert McMillan and changed his name in the 1970s in tribute to jazz legend John Coltrane, had his death registered by his former wife Rhona Gemmell.</p> <p dir="ltr">He was a veteran Scottish actor with a host of acting credits to his name, including his most well-known role as Hagrid in the <em>Harry Potter</em> films, the starring role as Valentin Dmitrovich Zukovsky in <em>Golden Eye</em> and <em>The World Is Not Enough</em>, and as Samuel Johnson in <em>Blackadder the Third</em>.</p> <p dir="ltr">Coltrane was also a prominent face in the series <em>Cracker</em>, starring as Dr Eddie Fitzgerald during his airing between 1993 and 2006.</p> <p dir="ltr">Once a heavy drinker and with a past that included drug use, his friend and late actor John Sessions said Coltrane had a “strong self-destructive streak” and a “deep, driving melancholy”.</p> <p dir="ltr">“Booze is my undoing,” Coltrane once said. “I can drink a gallon of beer and not feel the least bit drunk.”</p> <p dir="ltr">In his later years, the star suffered from osteoarthritis that left him wheelchair-bound and in “constant pain”.</p> <p dir="ltr">“I was fighting pain 24 hours a day when I was in <em>National Treasure</em> and <em>Great Expectations</em>,” he told the <em>Daily Express </em>in 2020.</p> <p dir="ltr">“I had no cartilage in my knee. It was bone on bone.”</p> <p><span id="docs-internal-guid-08a12e51-7fff-909f-a798-93a51c51782b"></span></p> <p dir="ltr"><em>Image: Getty Images</em></p>

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The queen’s death certificate says she died of ‘old age’. But what does that really mean?

<p>Queen Elizabeth’s <a href="https://www.nrscotland.gov.uk/news/2022/registrar-general-releases-extract-of-death-entry-for-hm-the-queen">newly released</a> death certificate contains just two curious words under her cause of death – old age.</p> <p>We might talk about people dying of old age in everyday speech. But who actually dies of old age, medically speaking, in the 21st century?</p> <p>Such a vague cause of death not only raises questions about how someone died, it can also be hard on family and loved ones left behind.</p> <p><strong>The many ways people die</strong></p> <p>The <a href="https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths/bulletins/deathsregistrationsummarytables/latest#leading-causes-of-death">leading causes of death</a> in England and Wales are dementia and Alzheimer’s disease; heart disease; cerebrovascular diseases (such as stroke); cancer; and COVID. Other notable causes include chronic lower respiratory diseases (such as asthma); influenza; and pneumonia.</p> <p>In fact, “old age” as a cause of death – alongside the vague description of “frailty” – is <a href="https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths/bulletins/monthlymortalityanalysisenglandandwales/august2022">often categorised</a> under “symptoms, signs, and ill-defined conditions”.</p> <p>This latter category is in the top ten causes of death. But this currently trails well below COVID, and on average over a five year period, below influenza and pneumonia.</p> <p><strong>An interesting history</strong></p> <p>Old age, as a category for causing death, has a <a href="https://www.cdc.gov/nchs/data/misc/classification_diseases2011.pdf">long history</a>. It was a leading cause of death in the 19th century, alongside the vague description of “found dead”.</p> <p>In the mid-19th century, <a href="https://www.parliament.uk/about/living-heritage/transformingsociety/private-lives/death-dying/dying-and-death/registeringdeath/">registering someone’s death</a> moved from clerical to secular, with the Births and Deaths Registration Act 1836 (UK).</p> <p>There was then the landmark publication, the <a href="https://www.amazon.com.au/Bertillon-Classification-Causes-Death/dp/1360651454">Bertillon Classification of Causes of Death</a>, written by French statistician and demographer Jacques Bertillon.</p> <p>Canadian philosopher Ian Hacking <a href="https://www.google.com.au/books/edition/The_Taming_of_Chance/ud7EzIBwQBwC?hl=en&amp;gbpv=1&amp;printsec=frontcover">wrote</a> that dying of anything other than what was on the official list was “illegal, for example, to die of old age”.</p> <p>We may say this is a bit hyperbolic. Surely, by the end of the 19th century, it was not illegal to die of old age?</p> <p>What this suggests is that providing a precise cause of death is important because it’s a valuable tool for tracking mortality trends at different levels of the population.</p> <p>Eventually, “old age” became a last resort phrase to describe an unknown cause of death. Or it became useful where a person may have died from a number of complications, but where it was not practical or ethical to order an autopsy to find the precise underlying cause of death.</p> <p><strong>There’s no closure</strong></p> <p>The other reason why “old age” has been seldom used as the cause of death in the 20th and 21st centuries was that it doesn’t provide any closure to families of the deceased.</p> <p><a href="https://eprints.qut.edu.au/221012/">Research</a> shows families want information about how their loved one died, not only because it can be useful for managing their own health concerns, but also because it provides a resolution to their loved one’s death.</p> <p>An unknown cause of death can exacerbate grief and trauma, particularly if the death was sudden or unexpected. Researchers <a href="https://www.google.com.au/books/edition/Continuing_Bonds/e8a7NjkzsbsC?hl=en&amp;gbpv=1&amp;printsec=frontcover">have long argued</a> families form continuing relationships with their loved one after they die. Ascertaining how they died is one part of how the family members left behind manage their grief and memorialise the deceased.</p> <p><strong>A good death</strong></p> <p>We may decide that asking for more information about how the queen died at the age of 96 is just macabre titillation. We may decide the royal family deserves privacy surrounding intimate details of the queen’s death.</p> <p>However, a specific cause of death of someone who lived a privileged life and who died at an old age, for instance, can tell us much about how to lead a healthy life and plan for a good death.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/191666/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><em>Written by Marc Trabsky. Republished with permission of <a href="https://theconversation.com/the-queens-death-certificate-says-she-died-of-old-age-but-what-does-that-really-mean-191666" target="_blank" rel="noopener">The Conversation</a>.</em></p> <p><em>Image: Getty Images</em></p>

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Train driving dream comes true for brain tumour survivor

<p dir="ltr">Three years after doctors found a large tumour growing in his brain, seven-year-old Broly Blackmore has seen his dream of becoming a train driver come true.</p> <p dir="ltr">The young boy from Hallett, South Australia, had the tumour removed when he was just four years old after he collapsed and was rushed to hospital by helicopter.</p> <p dir="ltr">If it wasn’t removed that night, doctors told his mother, Corrine Maidment, that he wouldn’t make it.</p> <p dir="ltr">In the years since, Broly’s life has become relatively normal, albeit with regular brain scans and physio trips - and he has had his wish of driving a train granted by the Starlight Foundation.</p> <p dir="ltr">The seven-year-old went on a trip on the Pichi Richi steam train, travelling from Quorn to Port Augusta as a “trainee train driver”.</p> <p dir="ltr">"Ever since he was only a couple of months old everything has always been about trains … diesels aren't as good as steam trains apparently," Ms Maidment said, adding that he barely slept the night before the big day.</p> <p dir="ltr">"According to everyone in the train, they weren't allowed to do anything without his say so … at one point, he told the fireman, the guy who does the coal, 'That's my seat. I need to sit there'.</p> <p dir="ltr">"He was boss for the day." </p> <p dir="ltr">The Pichi Richi railway, an outback steam train experience that has been operating since 1973, later shared a sweet photo of Broly on the train.</p> <p dir="ltr">“Last Sunday, Pichi Richi Railway was able to grant a wish for a very special visitor, 7 year old Broly who was having his wish granted with help from Starlight Children's Foundation Australia’s ‘Wishgranting Program’,” the railway <a href="https://www.facebook.com/PichiRichiRailway/posts/pfbid032C45MeP339xWYPL321ZTFjXXsehYJh7pWe2xkX812DkCLCBZgZyp8UVNGVzF7ztvl">wrote</a>.</p> <p dir="ltr">“Broly loves trains so Starlight contacted Pichi Richi Railway and Broly was lucky enough to ride in the cab of engine W934 for the day with our crew on the Pichi Richi Explorer service. </p> <p dir="ltr">“A very special day for our crew, Broly and his family.”</p> <p dir="ltr">Although Broly’s wish was given to him while he was in hospital, Ms Maidment said they had waited until he was old enough to decide how he wanted to spend it.</p> <p dir="ltr">"He's had the wish sitting there since he was in the hospital ... but we wanted to wait until he was old enough to make a decision himself so he'd know what the wish was and he'd remember it," she said. </p> <p><span id="docs-internal-guid-4354a857-7fff-0466-bb9f-4dd255b3ba47"></span></p> <p dir="ltr"><em>Images: Blackmore family, Starlight Foundation, Pichi Richi Railway (Facebook)</em></p>

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Your eyes could predict your risk of heart disease

<p dir="ltr">As well as being windows to the soul, <a href="https://www.oversixty.com.au/health/body/could-an-eye-test-predict-your-risk-of-heart-disease" target="_blank" rel="noopener">your eyes</a> could indicate your risk of developing heart disease according to new research.</p> <p dir="ltr">Scientists have developed imaging powered by Artificial Intelligence (AI) that can predict cardiovascular disease and death just by looking at the network of veins and arteries in your retina.</p> <p dir="ltr">Their findings could pave the way for a non-invasive and highly effective test that could replace the blood tests and blood pressure measurements currently used.</p> <p dir="ltr">With previous studies finding that the width of the tiny veins and arteries in the retina may be an accurate, early indicator for circulatory diseases including heart disease, cardiovascular disease, stroke, and heart failure.</p> <p dir="ltr">But, it was unclear whether these findings apply to both men and women, prompting the researchers to develop an AI-enabled algorithm called QUARTZ (QUantitative Analysis of Retinal vessels Topology and siZe) to develop models for assessing whether combining imaging of the retina with known risk factors could predict vascular health and death.</p> <p dir="ltr">They then applied models the algorithm created to retinal images of 88,052 people that are stored in the UK’s BioBank, as well as 7411 participants in the European Prospective Investigation into Cancer (EPIC)-Norfolk study, which tracked the health of participants for seven to nine years.</p> <p dir="ltr">The predictive model used known risk factors, including smoking, medical history, and age and was able to identify two-thirds of the participants who later died of circulatory disease who were most at risk.</p> <p dir="ltr">With retinal imaging already being common practice in the UK and US, the researchers argue that using changes to the retina and AI has the potential to reach a greater portion of the population than current testing methods.</p> <p dir="ltr">“[Retinal vasculature]is a microvascular marker, hence offers better prediction for circulatory mortality and stroke compared with [heart attack] which is more macrovascular, except perhaps in women,” they write.</p> <p dir="ltr">“In the general population it could be used as a non-contact form of systemic vascular health check, to triage those at medium-high risk of circulatory mortality for further clinical risk assessment and appropriate intervention.”</p> <p dir="ltr">Drs Ify Mordi and Emanuele Trucco of Scotland’s University of Dundee wrote in <a href="https://bjo.bmj.com/content/early/2022/09/12/bjo-2022-322517" target="_blank" rel="noopener">a separate editorial</a> that using changes to the retina to inform overall cardiovascular risk is “certainly attractive and intuitive” but is yet to form part of clinical practice.</p> <p dir="ltr">“Using retinal screening in this way would presumably require a significant increase in the number of ophthalmologists or otherwise trained assessors,” they write.</p> <p dir="ltr">“What is now needed is for ophthalmologists, cardiologists, primary care physicians and computer scientists to work together to design studies to determine whether using this information improves clinical outcome, and, if so, to work with regulatory bodies, scientific societies and healthcare systems to optimise clinical workflows and enable practical implementation in routine practice.”</p> <p dir="ltr">The study was published in the <em><a href="https://bjo.bmj.com/content/early/2022/08/23/bjo-2022-321842" target="_blank" rel="noopener">British Journal of Ophthalmology</a></em>.</p> <p><span id="docs-internal-guid-0bda2897-7fff-22ea-56e7-d43631ebe839"></span></p> <p dir="ltr"><em>Image: Getty Images</em></p>

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“Rest easy ma’am”: Tributes flow for singer Loretta Lynn

<p>Loretta Lynn, the country singer behind <em>Coal Miner’s Daughter</em> and <em>You Ain’t Woman Enough</em> and a leading feminist in the country music scene, has passed away aged 90.</p> <p>Her family broke the news in a statement on Twitter on Tuesday.</p> <p>“Our precious mom, Loretta Lynn, passed away peacefully this morning, October 4th, in her sleep at home in her beloved ranch in Hurricane Mills,” the statement read.</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">Loretta Lynn ♥️ A pioneering daughter that changed music and the world forever for all the daughters that followed. We’ll miss you but your spirit lives on! <a href="https://twitter.com/hashtag/thepill?src=hash&amp;ref_src=twsrc%5Etfw">#thepill</a> <a href="https://twitter.com/hashtag/forher?src=hash&amp;ref_src=twsrc%5Etfw">#forher</a> <a href="https://t.co/9XTPwLkVru">pic.twitter.com/9XTPwLkVru</a></p> <p>— The Chicks (@thechicks) <a href="https://twitter.com/thechicks/status/1577421929673543681?ref_src=twsrc%5Etfw">October 4, 2022</a></p></blockquote> <p>With a career spanning six decades, Lynn built her reputation as a feminist voice in the male-dominated world of country music, tackling issues including the freedom provided by birth control and the inequities of heterosexual relationships.</p> <p>Her choice of subject matter was controversial for country music in the 1960s and ‘70s, with Lynn telling one interviewer that 14 of her songs had been banned by radio stations.</p> <p>“I wasn’t the first woman in country music,” she said in a 2007 interview with <em>Esquire </em>magazine.</p> <p>“I was just the first one to stand up there and say what I thought, what life was about. The rest were afraid to.”</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">Loretta Lynn and Sissy Spacek after the 53rd Academy Awards (March 31, 1981).</p> <p>Spacek, who was personally selected by Lynn to portray her in the biographical musical film 'Coal Miner's Daughter,' earned the Best Actress Oscar for her performance as the country music icon. <a href="https://t.co/mbFnBhY1Ic">pic.twitter.com/mbFnBhY1Ic</a></p> <p>— The Academy (@TheAcademy) <a href="https://twitter.com/TheAcademy/status/1577424584709705728?ref_src=twsrc%5Etfw">October 4, 2022</a></p></blockquote> <p dir="ltr">Even so, Lynn became an icon of the genre with more than 50 top 10 hits according to her website.</p> <p dir="ltr">Lynn went on to become the first woman to win the Country Music Association’s ‘Entertainer of the Year’ award in 1972, as well as seven other CMA awards, 12 Academy of Country Music Awards, and three Grammy Awards as an artist.</p> <p dir="ltr">She won an additional two Grammys in 2004 for her work on the album <em>Van Lear Rose</em> in collaboration with White Stripes frontman Jack White, where she either wrote or co-wrote every song.</p> <p dir="ltr">The singer also received a Grammy Award for lifetime achievement in 2010.</p> <p dir="ltr">In 1988, she was voted into the Country Music Hall of Fame and in 2013 she was presented with a Presidential Medal of Freedom by then-president Barack Obama, who <a href="https://twitter.com/ObamaFoundation/status/1577428821590282242" target="_blank" rel="noopener">noted</a> that she “opened doors for women not only by winning tremendous achievements, but also by raising issues few dared to discuss”.</p> <p><span id="docs-internal-guid-d90b7fc5-7fff-0de4-1cad-b78e3987bb9e"></span></p> <p dir="ltr">Since the news of her passing broke, tributes have begun to flow for Lynn from fans, fellow singers and friends.</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">My heart is broken with the news of my sweet friend Loretta Lynn passing. I will remember all the sweet visits and laughs we shared. RIP sweet Angel. <a href="https://t.co/X5IqiD63an">pic.twitter.com/X5IqiD63an</a></p> <p>— Stella Parton (@StellaParton) <a href="https://twitter.com/StellaParton/status/1577314224078217217?ref_src=twsrc%5Etfw">October 4, 2022</a></p></blockquote> <p dir="ltr">Stella Parton penned an emotional tribute to her “sweet friend” and “angel”, accompanied by a photo of the pair together.</p> <p dir="ltr">“My heart is broken with the news of my sweet friend Loretta Lynn passing. I will remember all the sweet visits and laughs we shared. RIP sweet Angel,” Parton wrote.</p> <p dir="ltr"><span id="docs-internal-guid-6759ed07-7fff-3668-31d6-09c08f584b8e"></span></p> <p dir="ltr">“She was an inspiration. R.I.P. Loretta Lynn ❤️‍,” Carole King tweeted.</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">She was an inspiration.<br />R.I.P. Loretta Lynn ❤️ <a href="https://t.co/VqwmkcOAqy">pic.twitter.com/VqwmkcOAqy</a></p> <p>— Carole King (@Carole_King) <a href="https://twitter.com/Carole_King/status/1577318037912330240?ref_src=twsrc%5Etfw">October 4, 2022</a></p></blockquote> <p dir="ltr">“Joyous. Fierce. One of a kind. I loved meeting and working with Loretta Lynn ❤️‍🕊️🙏,” singer k.d. Lang <a href="https://twitter.com/kdlang/status/1577381590736388096" target="_blank" rel="noopener">shared</a>.</p> <p dir="ltr"><span id="docs-internal-guid-fadb031b-7fff-50fc-027c-01011cd9263e"></span></p> <p dir="ltr">“Loretta Lynn gave me this ring of hers many moons ago and I’ve cherished it ever since. Rest in peace. We will all miss you so dearly ❤️‍,” actress Brooke Shields said.</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">Loretta Lynn gave me this ring of hers many moons ago and I’ve cherished it ever since. Rest in peace. We will all miss you so dearly ❤️ <a href="https://t.co/KdgmIiXhXP">pic.twitter.com/KdgmIiXhXP</a></p> <p>— Brooke Shields (@BrookeShields) <a href="https://twitter.com/BrookeShields/status/1577371993611059232?ref_src=twsrc%5Etfw">October 4, 2022</a></p></blockquote> <p dir="ltr">American band The Oak Ridge Boys tweeted: “Loretta Lynn has gone home… Great Britain lost their Queen … now we have lost ours … Rest easy ma’am. You were loved by all … 😢”.</p> <p dir="ltr">Ken Burns, the documentarian behind Country Music, the 2019 miniseries that Lynn took part in, <a href="https://twitter.com/KenBurns/status/1577397952569643009" target="_blank" rel="noopener">wrote</a>: “Loretta Lynn turned life into song, providing a voice to the experiences of American women. </p> <p dir="ltr"><span id="docs-internal-guid-ef6ceebc-7fff-6fb8-a768-0e86d3fc59d3"></span></p> <p dir="ltr">“She will always be celebrated as a central part of the history of country music.”</p> <p dir="ltr"><em>Image: Getty Images</em></p>

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Queen Elizabeth's youngest maid of honour passes away

<p dir="ltr">The youngest of Queen Elizabeth’s maids of honour at her 1953 coronation passed away just one day before Her Majesty’s state funeral.</p> <p dir="ltr"><em>The Times</em> reported that Lady Mary Russell died on September 18, aged 88.</p> <p dir="ltr">“Lady Mary died peacefully at home with her family around her on Sunday 18 September,” the outlet’s obituary read.</p> <p dir="ltr">“Beloved wife of David, much-loved mother of Arabella, Anthony, Philip, Jason and Marina, and dearly loved by her 12 grandchildren.”</p> <p><span id="docs-internal-guid-256891b7-7fff-4e61-eff3-c37d885c2119"></span></p> <p dir="ltr">Lady Mary was 19 when she helped five other maids of honour in carrying the Queen’s six-metre train - which was so heavy the monarch would be unable to move without their hel[ - at Westminster Abbey during the coronation.</p> <p dir="ltr"><img src="https://oversixtydev.blob.core.windows.net/media/2022/09/qeii-coronation.jpg" alt="" width="1280" height="720" /></p> <p dir="ltr"><em>Queen Elizabeth II with her maids of honour Lady Moyra Campbell, Lady Anne Glenconner, Lady Rosemary Muir, Lady Mary Russell, the Baroness Willoughby de Eresby Jane Heathcote-Drummond-Willoughby, Lady Jane Rayne. Image: The Print Collector/Getty Images</em></p> <p dir="ltr">Her father, the Earl of Haddington, was a childhood friend of the Queen Mother and was pictured carrying the Sceptre of the Dove at George VI’s coronation in 1937.</p> <p dir="ltr">In a previous interview, Lady Mary recalled how “moving” and “overwhelming” the coronation was, as well as the honour of being one of a select few chosen to be involved in the ceremony.</p> <p dir="ltr">"It was overwhelming and moving – especially during the anointing… It was an incredible moment, but all I could think about was how heavy the embroidery felt," she said.</p> <p dir="ltr">"Of all the girls our age in the country, we six girls were chosen to carry the Queen's train and that meant a great deal."</p> <p dir="ltr">Fellow maid of honour Baroness Anne Glenconner told the <em>BBC</em> that they had a taste of fame during the 1950s as a result of their role in the historic occasion, describing them as “the Spice Girls of their time”.</p> <p dir="ltr">Lady Mary’s passing comes two years after the death of Lady Morya Campbell, another maid of honour, at the age of 90.</p> <p dir="ltr">Baroness Glenconner, along with Lady Jane Lacey, Lady Rosemary Muir and Baronness Willoughby de Eresby, is still alive today.</p> <p dir="ltr"><span id="docs-internal-guid-374db8d2-7fff-8d0b-8c98-b245f6100f68"></span></p> <p dir="ltr"><em>Image: Getty Images</em></p>

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If you experienced ‘Blursday’ during lockdown, you’re not alone

<p dir="ltr">After two years of mask-wearing, hand sanitising, lockdowns and social distancing, it’s safe to say we’re all experiencing some side effects of going through a global pandemic.</p> <p dir="ltr">If you feel like time has slowed down or Mondays feel like Wednesdays and Wednesdays feel like Fridays, you’ve likely experienced a feeling recently dubbed ‘Blursday’ - and you’re not the only one.</p> <p dir="ltr">A team of scientists have now captured what living in ‘Blursday’ is like, and have published their findings in the journal <em><a href="https://doi.org/10.1038/s41562-022-01419-2" target="_blank" rel="noopener">Nature Human Behaviour</a></em>.</p> <p dir="ltr">Using data from surveys conducted in nine countries - gathered through 14 questionnaires and 15 behavioural tasks - during the first two years of the pandemic, the team of researchers found that feelings of isolation affected our sense of time, including feelings of time grinding to a halt.</p> <p dir="ltr">Maximilien Chaumon, a researcher at the Institut du Cerveau et de la Moelle Épinière in France and coauthor on the study, told <em><a href="https://www.the-scientist.com/news-opinion/it-s-not-just-you-lockdowns-had-us-living-in-blursday-study-says-70422" target="_blank" rel="noopener">The Scientist</a></em> of how a fellow researcher saw COVID as an opportunity to gain an insight into the complex phenomenon that is our perception of time.</p> <p dir="ltr">“When we talk about our senses, [not] our sense of time but our sense of vision, touch, and so on, we think about those sensory receptors,” he explained.</p> <p dir="ltr">“And time perception does not have such receptors. It is a psychological construct, actually, that has a very multifactorial origin that is very complex.”</p> <p dir="ltr">Chaumon said the pandemic provided the perfect chance to collect data on this concept, explaining that our sense of time is incredibly influenced by our environment, emotional state and how isolated we are, which in turn can affect our wellbeing and mental health.</p> <p dir="ltr">“This is sort of the angle that triggered this study, in the sense that this massive disruption that COVID-19 created, with its lockdown, on our daily routine, the way we use our time, the way time unfolds during the day, and initial reports of people reporting being lost in their week, not knowing whether it was today or whether it was Monday or Tuesday and so on,” Chaumon added,</p> <p dir="ltr">By compiling a range of tasks to measure different aspects of our time perception, along with psychological scales that measure anxiety and depression, the team hoped to correlate the tasks and measures.</p> <p dir="ltr"><strong>Wibbly wobbly time causes wibbly wobbly health problems</strong></p> <p dir="ltr">Theirs isn’t the first to study our perception of time or the effects the pandemic have had on it.</p> <p dir="ltr"><a href="https://nam04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fu7061146.ct.sendgrid.net%2Fls%2Fclick%3Fupn%3D4tNED-2FM8iDZJQyQ53jATUaUp6sA-2BpAvcl9YHzVa412QC1m3ibG-2FC3WQYczSIN1ZeXjTw-2F-2FSDFk4BOzJ4zXx-2Fvw-3D-3DLypt_LUT5diG96CqPUCpHtTdEJL2b31V0MmXDDBFBEm0nPEbHc8MtQdGxiyqTf-2FzdAPZDSx9IaeyAwnFz9OTaNQFX-2BXQLL8NMAAKx-2FL8IrpwUjzdetB7ZKmCghKO52pZka6HGYFTMHI-2B-2Fe-2BJS6LfwGws67A744zSx8i0Vtoc20FSpJ-2FY8ZMNMbQJlM8bC-2FeElv-2B99BECt8HWdJ0JCLCokbTc4kBOuKcR5lBaDkTG2apoJrHyzEYaHEX-2Bx1-2B-2F82umfOSV3S2GvH5vXKwhUg7158G3vtov5dTRfjj5yJu2iMqiZQRyCHDmZg-2Bz4smKOIckwZVBpH-2BFGnRcww1nHSSSRxw-2FRTNWsefWy1jyO4slKTgvThQY-3D&amp;data=05%7C01%7Clilly.nguyen%40latimes.com%7C9f19770ffc344ce0549a08da853c1f96%7Ca42080b34dd948b4bf44d70d3bbaf5d2%7C0%7C0%7C637968790511475387%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&amp;sdata=bumpnIH0Ne%2BwT6N9Sv850G8Sd44L7vlbxB9aHIcysko%3D&amp;reserved=0" target="_blank" rel="noopener">Another study</a> published in 2022, based on surveys conducted in just the US, found that people have been losing their sense of time because of the pandemic, collective trauma caused by it, and additional challenges we’ve faced in recent times, including unemployment, financial hardships, supply shortages, death, and climate change.</p> <p dir="ltr">E. Alison Holman, a professor in nursing at UC Irvine who has been studying the relationship between trauma and time perception and is a co-author on the study, said in a recent interview that not addressing this change in how we sense time can put us at greater risks in terms of our mental health.</p> <p dir="ltr">“Having your sense of time get messed up to the extent that it really screws you up in terms of where you see yourself going in your life, in the context of the loneliness that people were experiencing and the social isolation, it’s an open question now that I’m trying to address,” Holman <a href="https://www.sciencedaily.com/releases/2022/08/220823170747.htm">said</a>.</p> <p dir="ltr">“How does that alter your sense of time? How might the social isolation of the pandemic have contributed to that alteration in your sense of time because you’re spending all of this time by yourself?</p> <p dir="ltr">"Given that distortions in time perception are a risk factor for mental health problems, our findings have potential implications for public health.”</p> <p dir="ltr"><strong>What can we do to readjust our sense of time?</strong></p> <p dir="ltr">According to Holman, regaining a sense of time relies on reintegrating our past and present, as well as rebuilding our future.</p> <p dir="ltr">“When you think about your life and who you are, you have a past. Your past is a big part of who you are today. We have a past, a present, which we are doing right now, and a future that we hope to get to,” Holman said.</p> <p dir="ltr">“What happens to people is they end up getting stuck in the trauma. As time moves on, they don’t mentally move on.</p> <p dir="ltr">“Being able to reintegrate one’s past with the present — knowing where I am now and where I’m going, the future. That’s really important for mental health.”</p> <p><span id="docs-internal-guid-ca153a76-7fff-3f89-a138-951f88cdc1ee"></span></p> <p dir="ltr"><em>Image: Getty Images</em></p>

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New photos show human side of Queen’s famed guards

<p dir="ltr">Rare, recently released photos have shown a behind-the-scenes look at the lives of the Queen’s guards in between lengthy shifts standing watch during her lying-in-state.</p> <p dir="ltr">The guards, known for their bearskin hats and stoic expressions, were guarding the Queen’s coffin around the clock in the lead-up to her funeral on Monday.</p> <p dir="ltr">But, recent photos shared by the UK Ministry of Defence show a more human side to them, with shots of them resting between shifts with their shoes and jackets off, napping and lounging in the parliament building, and dressing each other.</p> <p><span id="docs-internal-guid-e6a25eb5-7fff-7832-5ec6-4fd74261dd21"></span></p> <p dir="ltr">“The UK Armed Forces are continuing to honour their Commander-in-Chief of 70 years, Her Majesty The Queen,” the Ministry captioned the photos.</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">The UK Armed Forces are continuing to honour their Commander-in-Chief of 70 years, Her Majesty The Queen, as they stand vigil alongside The King's Body Guard. <a href="https://t.co/1iJi4xGGbJ">pic.twitter.com/1iJi4xGGbJ</a></p> <p>— Ministry of Defence 🇬🇧 (@DefenceHQ) <a href="https://twitter.com/DefenceHQ/status/1571454159404109830?ref_src=twsrc%5Etfw">September 18, 2022</a></p></blockquote> <p dir="ltr">Members of His Majesty’s Body Guard of the Honourable Corps of Gentlemen at Arms, the Royal Company of Archers and the Yeomen of the Guard guarded the Queen’s coffin during vigils and her funeral and switched places every 20 minutes during her lying-in-state.</p> <p dir="ltr">The new photos come after footage shared earlier this week captured the moment a member of the Royal Guard collapsed near the Queen’s coffin in front of mourners, falling face forward towards the stone floor and bracing himself at the last second.</p> <p dir="ltr">During Her Majesty’s funeral, Lance Sergeant Wordsworth of the First Battalion Coldstream Guards described the preparations made for the service, involving days of standing guard and rehearsals.</p> <p dir="ltr">"For the funeral of Her Majesty, I am involved in doing the street lining. We're also lining the route to St George's Chapel for when the Queen comes down," he said to the Ministry of Defence.</p> <p dir="ltr">"On Wednesday, September 14, I was part of the Guard of Honour at Buckingham Palace when the coffin was received, and then when Her Majesty left to be taken in the procession to Westminster Hall.</p> <p dir="ltr">"Obviously this has been planned for, and you can see how many people are with us, how it is trying to get them working in unison, but as a battalion. This is our bread and butter."</p> <p dir="ltr">The soldier added that it was an immense honour to take part in the late monarch’s funeral and a defining moment in any guard member’s career.</p> <p dir="ltr">"This is one of the biggest occasions, as sad as it may be, you're not going to define anything more in your army career than starting as a Queen's guard and probably finishing as a King's guard."</p> <p dir="ltr"><span id="docs-internal-guid-22e7cbaa-7fff-64cb-7607-ab8754f397a0"></span></p> <p dir="ltr"><em>Images: @DefenceHQ (Twitter)</em></p>

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Royal biographer hints at Queen's cause of death

<p dir="ltr">A royal expert claims Queen Elizabeth II was suffering from a “relatively painless” but “invariably fatal” condition before announcing her death 90 minutes before Buckingham Palace.</p> <p dir="ltr">In a video uploaded to YouTube at 5pm UK time, controversial royal biographer Lady Colin Campbell claimed the Queen had passed away at 2.37pm.</p> <p dir="ltr">Buckingham Palace announced the monarch’s passing 90 minutes later, at around 6.30pm UK time.</p> <p dir="ltr">Her announcement came at the end of a lengthy clip where the royal expert spoke about a condition the Queen was allegedly suffering from.</p> <p dir="ltr">Lady Campbell, who is most well-known for her books about Princess Diana and the Queen Mother, claimed that Her Majesty was suffering from a serious bone condition, though she wouldn’t reveal “the word that accurately conveys her diagnosis” out of respect for her “dignity and privacy”.</p> <p dir="ltr">“If she wants to reveal that word, or her advisors wish to reveal it, that is up to them. I don’t think one needs to use the word to get across the point that I think most people will be able to pick up, that this is a really serious situation,” Lady Campbell said in the video, prior to announcing the monarch’s passing.</p> <p dir="ltr">“The condition has been induced, in part, according to people who know her well, has been created by the tremendous stress to which she has been subjected over the last three years.”</p> <p dir="ltr">The Palace has not confirmed the Queen’s cause of death.</p> <p dir="ltr">“Can you imagine an older woman, as her life is winding down, and she is hoping to enjoy the last few years of her life in good health being bombarded by the tremendous abuse to which she and the monarchy have been subjected,” Lady Campbell said.</p> <p dir="ltr">She went on to say she had tried to warn people that the Queen was “far more ill than they thought she was” over the past few months.</p> <p dir="ltr">“I have on several occasions in the last few weeks, if not months, made the point that she had been affected to her bones. I used that repeatedly to get across the point that what she was suffering from was a malady of the bones,” she continued.</p> <p dir="ltr">“There are two maladies of the bones, one is more painful than the other. Fortunately the Queen’s malady, although it falls in the same category and condition of the more painful one, has been the less painful one.</p> <p dir="ltr">“It has been restrictive, and I will not go into the medical treatments she has been receiving. I have previously indicated that her bruising was due to cannulas and I have left it at that.”</p> <p dir="ltr">After the video cuts away, Lady Campell continued filming, claiming she had found out about the Queen’s passing.</p> <p dir="ltr">“Having just made this video it is with great sadness that I have to inform you that events have yet again overtaken one’s plans, and I am reliably informed that the Queen died at 14.37pm this afternoon,” she said.</p> <p dir="ltr">“And that the reason why the announcement has not been made so far is that they are waiting for Harry and Meghan to arrive at Balmoral, after which the announcement will be made.”</p> <p dir="ltr">Buckingham Palace went on to announce the news of Her Majesty’s passing before Harry arrived at Balmoral, while Meghan remained in London.</p> <p dir="ltr">“I think we should be very grateful for having had such a wonderful monarch,” Lady Campbell continued.</p> <p dir="ltr">“And I think we can be also grateful for the fact that her death was relatively painless. Bone cancer is not fun.</p> <p dir="ltr">“But she was fortunate enough to have the lesser of the forms of bone cancer, and she kept her spirits and her vitality to practically the end.</p> <p dir="ltr">“And now, I would say, my sympathies to all her loved ones, all her family, and really, all her subjects many of whom love her.”</p> <p dir="ltr">However, the <em><a href="https://www.couriermail.com.au/news/world/queen-elizabeths-cause-of-death-may-never-be-released/news-story/47ceca6491d9ef44b1d9112061674cdb" target="_blank" rel="noopener">Courier Mail</a></em> reported that medical experts said frailty and “geriatric syndrome” - a term describing a group of common health conditions older people experience that don’t fit in distinct disease categories - could have been contributors to her passing.</p> <p dir="ltr">Her symptoms reportedly met five of seven criteria used by Britain’s NHS to classify people as frail, including being over 85, having ongoing health conditions, requiring regular help, being forced to cancel activities and using a walking stick.</p> <p><span id="docs-internal-guid-1630db36-7fff-3f8c-cae6-c2b858607b4b"></span></p> <p dir="ltr">In the hours before her death, a statement from Buckingham Palace said doctors were “concerned” for the Queen’s health and that she was “comfortable” at Balmoral.</p> <p dir="ltr"><em>Images: Getty Images / Lady Colin Campbell (YouTube)</em></p>

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Tiny discovery could explain why our brains beat Neanderthal brains

<p dir="ltr">Our brains are incredibly complex, even in comparison to some of our closest animal relatives - and now we’re one step closer to knowing why.</p> <p dir="ltr">Human brains are made up of a whopping 86 billion neurons on average, which is up to three times more than primates.</p> <p dir="ltr">In a breakthrough study, scientists found that one change in our genes helps our brains develop more neurons than other animals, as well as our extinct cousins, the Neanderthals.</p> <p dir="ltr">Although our brains are roughly the same size as those belonging to Neanderthals, ours are differently shaped and allowed us to create technologies that our cousins never did.</p> <p dir="ltr">A team of scientists at the Max Planck Institute of Molecular Cell Biology and Genetics went looking for differences between our and Neanderthal brains and focused on the neocortex, a region of the brain behind our foreheads that is the largest and most recently developed part of our brain.</p> <p dir="ltr">While focusing on a particular gene, called <em>TKTL1</em>, the team found that the chain amino acids that make up the gene in modern humans has just one difference from the same gene in Neanderthals and other mammals.</p> <p dir="ltr">After looking at previously published data, they found that <em>TKTL1 </em>was mostly expressed in progenitor cells - a type of cell that can become more specialised cells - called basal radial glia, which are responsible for producing neurons during development.</p> <p dir="ltr">To test their findings, the researchers introduced the gene into two groups of mice, which don’t express either version of the gene. One group received the modern version of the gene which humans have, while the other received the archaic version.</p> <p dir="ltr">The mice with the modern form of the gene went on to produce more basal radial glia, which then resulted in more cortical neurons developing, in comparison to those with the older version of the gene.</p> <p dir="ltr">Repeating the experiment in ferrets, which also carry the older version of the gene and have folds in their brains, they found that animals with the modern gene produced more neurons and had larger brain folds.</p> <p dir="ltr">Finally, they went to verify their findings in human foetal neocortex cells - this time by removing the <em>TKTL1 </em>gene. Cells without the modern gene produced fewer of the progenitor cells.</p> <p dir="ltr">Although they stress that additional genes may be behind why we have more neurons than our relatives, Wieland Huttner, one of the researchers involved, said the study “makes the point that this one gene is an essential player” for shaping our big brains.</p> <p dir="ltr">Christoph Zollikofer, a paleoanthropologist at the University of Zurich who wasn’t involved in the study, said the study presents a “smoking gun” showing how our brains are different from those of Neanderthals.</p> <p dir="ltr">The study was published in the journal <em><a href="https://www.science.org/doi/10.1126/science.abl6422" target="_blank" rel="noopener">Science</a></em>.</p> <p><span id="docs-internal-guid-0b806d03-7fff-5ff5-12ff-39d6b4aa5fd5"></span></p> <p dir="ltr"><em>Image: Getty Images</em></p>

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Obituary: Farewell to Her Majesty Queen Elizabeth II

<p>In 1947, the then <a href="https://time.com/5298945/queen-elizabeth-princess/">Princess Elizabeth</a> was on a tour of <a href="https://www.readersdigest.co.uk/lifestyle/travel/exploring-cape-towns-revival">South Africa</a> with her parents when she celebrated her 21st birthday. It was on that coming-of-age occasion that she made a solemn public pledge to the people of the British Empire and Commonwealth: “I declare before you all that my whole life whether it be long or short shall be devoted to your service.” </p> <p>It was a promise she kept throughout her long life and extraordinary reign as <a href="https://www.readersdigest.co.uk/inspire/life/7-historic-moments-during-queen-elizabeth-iis-reign">Queen Elizabeth II</a>, even as the monarchy itself was forced to adapt and evolve with changing times. When, at the age of 25, Princess Elizabeth Alexandra Mary became the <a href="https://www.readersdigest.co.uk/culture/celebrities/when-she-was-a-princess">42nd sovereign of England</a>, her subjects and citizens numbered 539 million, more than a quarter of the human race. By the conclusion of her reign, as the age of Empire drew to a close, that figure had fallen by two-thirds. </p> <p>Her steadfastness was all the more remarkable considering the Queen only attained the throne by virtue of her uncle [<a href="https://www.readersdigest.co.uk/inspire/life/vintage-readers-digest-1988-a-right-royal-quiz">Edward VIII</a>]’s shocking abdication in 1936, however, the trauma this event caused her family and subjects no doubt helped explain her determination not to shirk her own responsibilities. </p> <p>Her workload was constant and immense. Every day of the year, her morning started at her desk—whether at Buckingham Palace, Windsor Castle, or another royal residence—working through her boxes. These were full of correspondence earmarked for her attention, including requests for help, invitations, information from overseas territories where she remained sovereign, and British government papers she was required to sign.  </p> <p>In her position as the nation’s constitutional head, she offered a sense of constancy in the midst of social and political waves of change. She reigned through post-war Britain, the formation of the Commonwealth, the Swinging Sixties, domestic and international conflicts, the rise and fall of trade unions and the dramatic impact of technology.  </p> <p>Her first Prime Minister was <a href="https://www.readersdigest.co.uk/culture/film-tv/churchill-an-interview-with-brian-cox-and-miranda-richardson">Sir Winston Churchill</a> and 14 others followed. For each of them, from both sides of Westminster’s political chamber, her weekly audiences provided a boost, sometimes a balm and always discreet fount of wisdom built on her decades of experience. </p> <p>Publicly, the Queen stayed firmly out of politics, focusing instead on her 600-plus patronages and other platforms for charity work. She always said she “had to be seen to be believed” and well into her tenth decade, continued to attend hundreds of engagements every year.  </p> <p>She was as equally familiar a figure abroad, becoming one of the most central and respected leaders on the world stage. Her travels over the course of her reign saw her visit an estimated 110 countries, although no trip more significant than one to Northern Ireland in 2012, which saw her shake hands with Sinn Fein leader Martin McGuiness, 32 years after the murder of her cousin Lord Louis Mountbatten at Republicans’ hands.  </p> <p>At home, the Queen entertained guests from the White House to Wellington, including some controversial characters. With her clear grasp of the role of constitutional monarchy in statecraft, she was able to support many a diplomatic mission with her gold-plated banquets and lots of personal charm. </p> <p>At her side on hundreds of those occasions was her husband of 73 years, Prince Philip, Duke of Edinburgh, a strong-minded man nevertheless content to play second fiddle to his wife in public, and support her in every way. Behind the scenes, he was the undisputed boss of their family and household, and on their golden wedding anniversary, Elizabeth credited him as her “strength and stay”. </p> <p>Together, they withstood the personal trials of the royal family, starting with the Queen’s sister Margaret’s wish to marry the divorced Peter Townsend in the 1950s, before she changed her mind. Later, the Queen and Duke could only watch as three of their four children were divorced—these scandals dominating newspaper headlines, threatening to undermine the monarchy and, along with a huge fire at her beloved Windsor Castle, contributing to what Her Majesty described as her “annus horribilis” in 1992.  </p> <p>The Queen’s connection with her subjects was tested even more sharply in 1997 following the death of her former daughter-in-law, <a href="https://www.readersdigest.co.uk/inspire/life/intriguing-mysteries-the-death-of-princess-diana">Diana, Princess of Wales</a>. While the monarch focused on comforting her grandsons, her public silence drew huge criticism until eventually, she gave a moving and clearly sincere tribute.   </p> <p>As she said herself, lessons were learned from this period and the years that followed saw the Queen adopt a more open and accessible style, often smiling and joking, even jumping for joy when one of her horses won a race and participating in the London <a href="https://www.readersdigest.co.uk/culture/celebrities/interview-danny-boyle">Olympics opening ceremony</a>. </p> <p>Her final years saw her withstand the constraints of lockdown and the loss of her husband with her customary fortitude, bolstered by the support of her closest family members, devoted friends and always admiring public. Many of her subjects who openly criticised the institution of monarchy declared themselves impressed by the Queen herself, and agreed with her legions of fans that for all her time on the Throne, the British Crown was in very safe hands.  </p> <p>Throughout her extraordinary reign, Queen Elizabeth II’s life was one of service to her people, never wavering for one minute from the pledge she’d made on her 21st birthday, all those years before.  </p> <p><em>Image credits: Getty Images</em></p> <p><em>This article originally appeared on <a href="https://www.readersdigest.com.au/culture/obituary-farewell-to-her-majesty-queen-elizabeth-ii" target="_blank" rel="noopener">Reader's Digest</a>. </em></p>

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"She's really left us": Stunning double rainbow graces the skies

<p>As news of Queen Elizabeth's passing broke, people in the UK took to the gates of both Buckingham Palace and Windsor Castle to pay their respects to the monarch. </p> <p>As mourners gathered arm-in-arm to remember their Queen, they were graced with an emotional and magical sight. </p> <p>A spectacular double rainbow appeared over the dreary skies of London, with devastated Brits saying the Queen "sent us a sign" and that she has "really left us".</p> <p>The double rainbow even appeared over the Victoria memorial, prompting some to say it is "Queen Elizabeth with Prince Phillip". </p> <p>One twitter user said, "The rainbow at Windsor Castle made me cry. The rainbow Queen sent us a sign."</p> <p>Another said, "A rainbow breaks out, as the Union Jack is lowered to half-mast at Windsor tonight. A remarkable image. Farewell, Ma'am."</p> <p dir="ltr">The monarch was under medical supervision due to her deteriorating health but unfortunately died at Balmoral Castle in Scotland on September 8th at 8:30pm local time (3:30am AEDT).</p> <p dir="ltr">“The Queen died peacefully at Balmoral this afternoon,” The Royal Family tweeted.</p> <p dir="ltr">“The King and The Queen Consort will remain at Balmoral this evening and will return to London tomorrow.”</p> <p dir="ltr">The public was notified of her death through the traditional form of a formal message placed on an easel on the railings outside the Palace.</p> <p dir="ltr"><em>Image credits: Getty Images / BBC News</em></p>

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Inhalers and other steroids linked to changes in the brain

<p dir="ltr">If you’ve been diagnosed with asthma, Chronic Obstructive Pulmonary Disorder (COPD), ezcema or even Crohn’s disease, you’ve likely been prescribed some form of medical steroid to treat it.</p> <p dir="ltr">However, Dutch scientists are calling for more awareness about potential side effects of using medical steroids, as well as research into alternative treatment options, after they found a link between using these medications and changes in the brain structure and volume.</p> <p dir="ltr">Glucocorticoids, a class of synthetic steroids found in inhalers and other medicines, fight inflammation in the body, making them highly effective for treating autoimmune diseases, where your body triggers inflammation by mistake and results in your immune system attacking healthy cells as if they were viruses or bacteria. </p> <p dir="ltr">This immunoprotective quality has made them one of the most frequently prescribed drugs globally.</p> <p dir="ltr">But, both systemic and inhaled steroid use is associated with abnormalities in brain structure and shrinkage of particular areas, according to previous research.</p> <p dir="ltr">With this research focusing on small groups of people with specific conditions, a team of Dutch researchers decided to investigate whether these side effects were seen in the broader population, with their findings published in the journal <em><a href="https://doi.org/10.1136/bmjopen-2022-062446" target="_blank" rel="noopener">BMJ Open</a></em>.</p> <p dir="ltr">Using data from the UK Biobank - a database of genetic and health information from half a million people available to researchers across the world - the team looked to see whether there were differences in the brains of users and non-users of glucocorticoids.</p> <p dir="ltr">After comparing the brain scans of 222 people who use systemic steroids, 557 using inhaled steroids, and 24,106 people who didn’t use either, they found that use of medical steroids was linked to less intact white brain matter in comparison to scans of non-users.</p> <p dir="ltr">The white matter in our brains is made up of bundles of nerve fibres covered in a fatty substance called myelin, which gives these areas their white colour. White matter is part of the central nervous system, helping to connect different areas of grey matter to each other and send messages between them. These parts of the brain affect how we learn and how our brains function.</p> <p dir="ltr">Participants in the study also filled out a questionnaire to assess aspects of their mood over the previous fortnight, as the team wanted to know if steroid use was also linked to changes in processing speed or emotional responses.</p> <p dir="ltr">They found that systemic use of steroids was associated with a larger caudate - a C-shaped structure in the brain that is involved in associative and procedural learning, working memory, speaking in multiple languages, cognition and emotional processing.</p> <p dir="ltr">Meanwhile, the use of inhaled steroids was linked to a smaller amygdala, another structure in the brain made of grey matter that is involved in processing emotions, particularly for strong emotions such as fear.</p> <p dir="ltr">From the questionnaire, the team found systemic steroid users performed worse than non-users when it came to the test measuring processing speed, and that they reported significantly more symptoms of depression, apathy, restlessness, fatigue and lethargy.</p> <p dir="ltr">Inhaled steroid users also reported more tiredness and lethargy, but to a lesser degree than systemic users.</p> <p dir="ltr">But, the researchers stress that their findings don’t necessarily mean that medical steroids cause the changes seen in the brain.</p> <p dir="ltr">“Although a causal relation between glucocorticoid use and changes in the brain is likely based on the present and previous studies, the cross-sectional nature of this study does not allow for formal conclusions on causality,” they caution.</p> <p dir="ltr">Instead, they say the relationship may explain some of the side effects associated with long-term use of the medications, including anxiety, depression, mania and delirium.</p> <p dir="ltr">“While it remains unclear whether the observed effect sizes have clinical consequences for the population of glucocorticoid users as a whole, these findings are remarkable given the common neuropsychiatric side effects of synthetic glucocorticoids,” the researchers write.</p> <p dir="ltr">They conclude that widespread reduction in the integrity of white matter in the brain is associated with both systemic and inhaled steroid use, and argue that this could be an underlying contributor to neuropsychiatric side effects that patients using these steroids can experience.</p> <p><span id="docs-internal-guid-954fbbed-7fff-5e9e-2f6e-456381994a6a"></span></p> <p dir="ltr">Given the widespread use of medical steroids, they add that it’s important for doctors and patients to know about the possible effects they can have on the brain and that more research should be done into alternative options for treatment.</p> <p dir="ltr"><em>Image: Getty Images</em></p>

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